CJC-1295 (with DAC) 5MG

CJC-1295 (with DAC) is a synthetic analog of the native peptide GHRH (Growth Hormone-Releasing Hormone), designed for research applications in endocrine biology and pharmacology. The inclusion of deamino-cysteinyl (DAC) stabilizes the peptide, enhancing its structural integrity and metabolic stability for experimental use.

Research Context

CJC-1295 has been extensively studied as a potent stimulator of pituitary growth hormone (GH) secretion. Originally developed in the early 1990s, its mechanism of action involves binding to growth hormone-releasing hormone receptors (GHRHR) in somatotropes of the anterior pituitary gland. This interaction elicits a cascade of intracellular signaling events that ultimately result in GH release into the circulation. The DAC modification further reduces immunogenic potential while maintaining biological efficacy.

Research Overview

CJC-1295 with DAC serves as a valuable research tool in investigating the physiological and pharmacological properties of GH-secreting pathways. Its use has facilitated studies on:

Key Research Focus Areas

• Endocrine Function Analysis: Examination of pituitary-hypothalamic axis regulation, particularly in models of hypogonadism or GH deficiency.
• Pharmacokinetics and Stability: Investigations into peptide degradation pathways and formulation optimization for prolonged biological activity.
• Comparative Pharmacology: Contrasting effects of CJC-1295 with DAC against native GHRH and other synthetic analogs.
• Neuroendocrine Research: Evaluation of CNS regulation of GH secretion in experimental animal models.
• Biomarker Development: Identification of molecular markers associated with GH response to CJC-1295 administration.

Important Cautions

This material is intended exclusively for academic and institutional research purposes. Due to its potent hormonal effects, CJC-1295 with DAC requires careful handling and standardized experimental protocols to ensure safety and reproducibility. Research institutions employing this peptide must adhere to established ethical guidelines and regulatory standards for peptide synthesis and storage.

Storage Recommendations

For optimal stability, CJC-1295 (with DAC) should be stored at temperatures between 2°C to 8°C in a sealed, sterile environment. Once reconstituted, the solution may be refrigerated for up to 24 hours. All experimental waste containing this peptide must be disposed of according to institutional biohazard protocols.

For research use only. Not for human or animal consumption.